Description :

Since these discoveries insertional mutagenesis has been used to identify novel cancer genes in a variety of tumor types in animal models of cancer more recent work has developed novel insertional mutagens such as transposons that have broader capabilities to model cancer in vivo. The goal of this work is summarize the contribution that insertional mutagenesis has made to our understanding of cancer a variety of insertional mutagens are presented that have been used to study a variety of tumor types in several model organisms in addition the impact of insertional. Division of molecular genetics centre of biomedical genetics and cancer genomics centre the netherlands cancer institute 1066 cx amsterdam the netherlands e mail abernsnkinl aj dupuy da largaespada eds insertional mutagenesis strategies 1 in cancer genetics doi 101007 978 1 4419 7656 7 1 c springer science business media . A variety of insertional mutagens are presented that have been used to study a variety of tumor types in several model organisms in addition the impact of insertional mutagenesis in several gene therapy trials is discussed along with strategies to avoid such complications in future clinical trials. Abstract cancer arises largely as a result of mutations in genes regulating growth and differentiation of cells in most tumors multiple genes are usually affected resulting in either loss or gain of function of the encoded protein